Chicken γδ T cells proliferate upon IL-2 and IL-12 treatment and show a restricted receptor repertoire in cell culture

In chickens, γδ T cells represent a large fraction of peripheral T cells; however, their function remains largely unknown. Here, we describe the selective in vitro expansion of γδ T cells from total splenocytes by stimulation with the cytokines IL-2 and IL-12. Under these conditions, γδ T cells prol...

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Bibliografische Detailangaben

Hauptverfasser:	Antonia E. Linti, Thomas W. Göbel, Simon P. Früh
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2024-02-01
Schriftenreihe:	Frontiers in Immunology
Schlagworte:	chicken γδ TCR IL-2 IL-12 in vitro culture γδ T cell subsets TCR repertoire analysis
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1325024/full
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