Impact of neuroendocrine neoplasm-specific systemic treatments on expression and function of CXCR4 in neuroendocrine tumor cells

Abstract As neuroendocrine neoplasms (NEN) undergo increasing dedifferentiation, CXC chemokine receptor type 4 (CXCR4) becomes upregulated. Higher levels of CXCR4 are associated with invasive growth, metastasis formation, and poor prognosis. CXCR4 is considered a potential diagnostic biomarker and a...

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Auteurs principaux:	Christof Däubler, Clara Böttcher, Laura-Sophie Landwehr, Alexander Meining, K. Michalski, F. Reiter, Rudolf A. Werner, Philipp Hartrampf, Dorothee Rogoll, Alexander Weich
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2026-01-01
Collection:	Scientific Reports
Sujets:	Neuroendocrine neoplasm CXCR4 Cisplatin Everolimus Temozolomide Systemic therapy
Accès en ligne:	https://doi.org/10.1038/s41598-026-37026-8
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