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Synthesis and Anticandidal Activity of New Imidazole-Chalcones

In the present work, 15 new 1-(4-(1H-imidazol-1-yl)phenyl)-3-(4-substituedphenyl)prop-2-en-1-one derivatives (3a–3o) were synthesized to evaluate their antifungal activity. Structures of newly synthesized imidazole derivatives (3a–3o) were characterized by IR, 1H-NMR, 13C-NMR, and LCMSMS spectroscop...

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Principais autores: Derya Osmaniye, Betul Kaya Cavusoglu, Begum Nurpelin Saglik, Serkan Levent, Ulviye Acar Cevik, Ozlem Atli, Yusuf Ozkay, Zafer Asim Kaplancikli
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2018-04-01
coleção:Molecules
Assuntos:
imidazole
anticandidal activity
ergosterol inhibition
14-alpha demethylase
docking study
Acesso em linha:http://www.mdpi.com/1420-3049/23/4/831
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