Multiple CH/π Interactions Maintain the Binding of Aflatoxin B1 in the Active Cavity of Human Cytochrome P450 1A2

Human cytochrome P450 1A2 (CYP1A2) is one of the key CYPs that activate aflatoxin B1 (AFB1), a notorious mycotoxin, into carcinogenic exo-8,9-epoxides (AFBO) in the liver. Although the structure of CYP1A2 is available, the mechanism of CYP1A2-specific binding to AFB1 has not been fully clarified. In...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Jun Wu, Sisi Zhu, Yunbo Wu, Tianqing Jiang, Lingling Wang, Jun Jiang, Jikai Wen, Yiqun Deng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2019-03-01
Colecção:	Toxins
Assuntos:	CH/π interaction cytochrome P450 CYP1A2 aflatoxin specificity
Acesso em linha:	http://www.mdpi.com/2072-6651/11/3/158
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!