Controlled in vivo Bone Formation and Vascularization Using Ultrasound-Triggered Release of Recombinant Vascular Endothelial Growth Factor From Poly(D,L-lactic-co-glycolicacid) Microbubbles

Bone defects are challenging to treat in musculoskeletal system due to the lack of vascularization. Biomaterials with internal vascularization ability and osteoinduction bioactivity are promising strategies for orthopedic applications. Vascular endothelial growth factor (VEGF) has been widely used f...

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Автори:	Yong Gong, Songjian Li, Wei Zeng, Jianing Yu, Yan Chen, Bo Yu
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2019-04-01
Серія:	Frontiers in Pharmacology
Предмети:	bone defect vascular endothelial growth factor angiogenesis ultrasound osteogenesis
Онлайн доступ:	https://www.frontiersin.org/article/10.3389/fphar.2019.00413/full
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