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HER2-targeting Peptide Drug Conjugate with Better Penetrability for Effective Breast Cancer Therapy

Antibody-drug conjugates (ADCs) have the following advantages: target specificity; wide therapeutic index; and prolonged circulation half-life. A key limitation of ADCs, however, is the large size (~150 kDa), which markedly slows diffusion through the interstitium of solid tumors and prevents effici...

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Principais autores: Yixia Liang, Rong Lei, Jiabao Tan, Junyue Fang, Lin Yu, Shiyu Tan, Yan Nie, Qiongchao Jiang, Xiaoyun Xiao, Phei Er Saw
Format: Artigo
Sprog:Inglês
Udgivet: Compuscript Ltd 2023-12-01
Serier:BIO Integration
Fag:
breast cancer
cancer therapeutics
enhanced tumor penetration
her2
peptide-drug conjugate
Online adgang:https://www.ingentaconnect.com/contentone/cscript/bioi/2023/00000004/00000004/art00004
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