Exploring the Interaction of G-quadruplex Binders with a (3 + 1) Hybrid G-quadruplex Forming Sequence within the PARP1 Gene Promoter Region

The enzyme PARP1 is an attractive target for cancer therapy, as it is involved in DNA repair processes. Several PARP1 inhibitors have been approved for clinical treatments. However, the rapid outbreak of resistance is seriously threatening the efficacy of these compounds, and alternative strategies...

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Principais autores:	Stefania Mazzini, Salvatore Princiotto, Roberto Artali, Loana Musso, Anna Aviñó, Ramon Eritja, Raimundo Gargallo, Sabrina Dallavalle
格式:	Artigo
语言:	Inglês
出版:	MDPI AG 2022-07-01
丛编:	Molecules
主题:	G-quadruplex PARP1 promoter stabilizing ligand NMR circular dichroism fluorescence
在线阅读:	https://www.mdpi.com/1420-3049/27/15/4792
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