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Chromatin protein complexes involved in gene repression in lamina-associated domains

Abstract Lamina-associated domains (LADs) are large chromatin regions that are associated with the nuclear lamina (NL) and form a repressive environment for transcription. The molecular players that mediate gene repression in LADs are currently unknown. Here, we performed FACS-based whole-genome gen...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Stefano G Manzo, Abdelghani Mazouzi, Christ Leemans, Tom van Schaik, Nadia Neyazi, Marjon S van Ruiten, Benjamin D Rowland, Thijn R Brummelkamp, Bas van Steensel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Nature 2024-09-01
Schriftenreihe:The EMBO Journal
Schlagworte:
Lamina-associated Domains
Gene Repression
Chromatin
Nuclear Lamina
Mediator
Online-Zugang:https://doi.org/10.1038/s44318-024-00214-1
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