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A Pilot, Open-Label Study to Evaluate the Efficacy of Intra-Articular Administration of a Caninized TNF Receptor Fc Fusion Protein as a Treatment for Osteoarthritis-Associated Joint Pain

Tumor necrosis factor-α (TNF-α) is a potential target for osteoarthritis (OA) treatment. In several recent clinical studies in human OA, anti-TNF-α therapy showed promising results; however, these were open-label and based on patient-reported outcome measures. In this study, we developed a caninized...

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Principais autores: Aoi Nakanishi, B. Duncan X. Lascelles, Julie Allen, Beth Case, David Gearing, Masataka Enomoto
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-06-01
Serier:Frontiers in Veterinary Science
Fag:
osteoarthritis
joint pain
TNF-α
force plate
limb use asymmetry test
Online adgang:https://www.frontiersin.org/articles/10.3389/fvets.2022.836709/full
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