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Treatment of Trypanosoma cruzi with 2-bromopalmitate alters morphology, endocytosis, differentiation and infectivity

Abstract Background The palmitate analogue 2-bromopalmitate (2-BP) is a non-selective membrane tethered cysteine alkylator of many membrane-associated enzymes that in the last years emerged as a general inhibitor of protein S-palmitoylation. Palmitoylation is a post-translational protein modificatio...

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Principais autores: Cassiano Martin Batista, Rafael Luis Kessler, Iriane Eger, Maurilio José Soares
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-08-01
Serier:BMC Cell Biology
Fag:
2-Bromopalmitate
2-BP inhibition
Differentiation
Endocytosis
Palmitoylation
Trypanosoma cruzi
Online adgang:http://link.springer.com/article/10.1186/s12860-018-0170-3
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