Mice Carrying ALS Mutant TDP-43, but Not Mutant FUS, Display In Vivo Defects in Axonal Transport of Signaling Endosomes

Summary: Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease resulting from a complex interplay between genetics and environment. Impairments in axonal transport have been identified in several ALS models, but in vivo evidence remains limited, thus their pathogeneti...

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Hauptverfasser:	James N. Sleigh, Andrew P. Tosolini, David Gordon, Anny Devoy, Pietro Fratta, Elizabeth M.C. Fisher, Kevin Talbot, Giampietro Schiavo
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2020-03-01
Schriftenreihe:	Cell Reports
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211124720302527
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