Fluorescent image-guided surgery in breast cancer by intravenous application of a quenched fluorescence activity-based probe for cysteine cathepsins in a syngeneic mouse model

Abstract Purpose The reoperation rate for breast-conserving surgery is as high as 15–30% due to residual tumor in the surgical cavity after surgery. In vivo tumor-targeted optical molecular imaging may serve as a red-flag technique to improve intraoperative surgical margin assessment and to reduce r...

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Bibliografiske detaljer

Principais autores:	Frans V. Suurs, Si-Qi Qiu, Joshua J. Yim, Carolien P. Schröder, Hetty Timmer-Bosscha, Eric S. Bensen, John T. Santini, Elisabeth G. E. de Vries, Matthew Bogyo, Gooitzen M. van Dam
Format:	Artigo
Sprog:	Inglês
Udgivet:	SpringerOpen 2020-09-01
Serier:	EJNMMI Research
Fag:	Image-guided surgery (IGS) Quenched fluorescent activity-based probe (qABP) Cathepsin targeting Indocyanine green (ICG) Breast cancer
Online adgang:	http://link.springer.com/article/10.1186/s13550-020-00688-0
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