Safety and tolerability of losartan to treat recessive dystrophic epidermolysis bullosa in children (REFLECT): an open-label, single-arm, phase 1/2 trialResearch in context

Summary: Background: Recessive dystrophic epidermolysis bullosa (RDEB) is a skin fragility disorder characterised by life-long mechanically induced skin blistering, fibrosis-driven pseudosyndactyly, and multi-organ involvement. Preclinical studies have suggested mitigated progression by angiotensin...

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Ngā kaituhi matua:	Dimitra Kiritsi, Franziska Schauer, Stella Gewert, Katja Reineker, Antonia Reimer-Taschenbrecker, Agnes Schwieger-Briel, Hagen Ott, Claudia Schmoor, Olga Grishina, Dedee Murrell, Brigitte Stiller, Tobias Zahn, Alexander Nyström, Leena Bruckner-Tuderman
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2024-11-01
Rangatū:	EClinicalMedicine
Ngā marau:	Genetic blistering disorder Dystrophic epidermolysis bullosa COL7A1 Symptom relief therapy Skin fragility
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S2589537024004796
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!