Heroin Self-Administration and Extinction Increase Prelimbic Cortical Astrocyte–Synapse Proximity and Alter Dendritic Spine Morphometrics That Are Reversed by N-Acetylcysteine

Clinical and preclinical studies indicate that adaptations in corticostriatal neurotransmission significantly contribute to heroin relapse vulnerability. In animal models, heroin self-administration and extinction produce cellular adaptations in both neurons and astrocytes within the nucleus accumbe...

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Detalhes bibliográficos

Principais autores:	Benjamin M. Siemsen, Adam R. Denton, Jeffrey Parrila-Carrero, Kaylee N. Hooker, Eilish A. Carpenter, Meagan E. Prescot, Ashley G. Brock, Annaka M. Westphal, Mary-Nan Leath, John A. McFaddin, Thomas C. Jhou, Jacqueline F. McGinty, Michael D. Scofield
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-07-01
coleção:	Cells
Assuntos:	heroin astrocytes GFAP N-acetylcysteine prelimbic dendritic spines
Acesso em linha:	https://www.mdpi.com/2073-4409/12/14/1812
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