Targeted reversion of induced pluripotent stem cells from patients with human cleidocranial dysplasia improves bone regeneration in a rat calvarial bone defect model

Abstract Background Runt-related transcription factor 2 (RUNX2) haploinsufficiency causes cleidocranial dysplasia (CCD) which is characterized by supernumerary teeth, short stature, clavicular dysplasia, and osteoporosis. At present, as a therapeutic strategy for osteoporosis, mesenchymal stem cell...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Akiko Saito, Akio Ooki, Takashi Nakamura, Shoko Onodera, Kamichika Hayashi, Daigo Hasegawa, Takahito Okudaira, Katsuhito Watanabe, Hiroshi Kato, Takeshi Onda, Akira Watanabe, Kenjiro Kosaki, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Teruo Sakamoto, Akira Yamaguchi, Kenji Sueishi, Toshifumi Azuma
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	BMC 2018-01-01
סדרה:	Stem Cell Research & Therapy
נושאים:	Cleidocranial dysplasia RUNX2 iPSCs Osteoblasts Osteogenesis CRISPR/Cas
גישה מקוונת:	http://link.springer.com/article/10.1186/s13287-017-0754-4
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!