Toll-like Receptor-9 (TLR-9) Signaling Is Crucial for Inducing Protective Immunity following Immunization with Genetically Modified Live Attenuated <i>Leishmania</i> Parasites

No human vaccine is available for visceral leishmaniasis (VL). Live attenuated centrin gene-deleted <i>L. donovani</i> (<i>LdCen^−/−</i>) parasite vaccine has been shown to induce robust innate immunity and provide protection in animal models. Toll-like receptors (TLRs) are expressed in in...

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Autori principali:	Parna Bhattacharya, Sreenivas Gannavaram, Nevien Ismail, Ankit Saxena, Pradeep K. Dagur, Adovi Akue, Mark KuKuruga, Hira L. Nakhasi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2023-03-01
Serie:	Pathogens
Soggetti:	visceral leishmaniasis dendritic cells myeloid differentiation primary response 88 nuclear factor-kappa B cytokines costimulatory molecules
Accesso online:	https://www.mdpi.com/2076-0817/12/4/534
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