Anti-osteopontin therapy leads to improved edema and infarct size in a murine model of ischemic stroke

Abstract Ischemic stroke is a serious neurological disorder that is associated with dysregulation of the neurovascular unit (NVU) and impairment of the blood–brain barrier (BBB). Paradoxically, reperfusion therapies can aggravate NVU and BBB dysfunction, leading to deleterious consequences in additi...

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Detalhes bibliográficos

Principais autores:	Daniel Spitzer, Tim Puetz, Moritz Armbrust, Maika Dunst, Jadranka Macas, Florian Croll, Karl-Heinz Plate, Yvonne Reiss, Stefan Liebner, Patrick N. Harter, Sylvaine Guérit, Kavi Devraj
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2022-12-01
coleção:	Scientific Reports
Acesso em linha:	https://doi.org/10.1038/s41598-022-25245-8
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