Quantitative 3D reconstruction of viral vector distribution in rodent and ovine brain following local delivery

Viral vectors are an active area of research and development to treat diseases of the central nervous system (CNS). However, systemic delivery of large-molecular weight biologics is complicated by limited crossing of the blood-brain barrier, immunological clearance from the circulation, off-target e...

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Auteurs principaux:	Roberta Poceviciute, Kenneth Mitchell, Angeliki Maria Nikolakopoulou, Suehyun K. Cho, Xiaobo Ma, Phillip Chen, Samantha Figueroa, Ethan J. Sarmiento, Aryan Singh, Oren Hartstein, William G. Loudon, Florent Cros, Alexander S. Kiselyov
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2024-12-01
Collection:	NeuroImage: Reports
Sujets:	Local drug delivery Central nervous system Gene therapy Adeno-associated virus Quantitative image analysis 3D reconstruction
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2666956024000242
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