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Establishment of a human TLR4 compound heterozygous knockout hESC line (WAe009-A-N) to model toll-like receptor 4 deficiency by CRISPR/Cas9 system

Toll-like receptor 4 (TLR4) is a pattern recognition receptor (PRRS) and an important protective immune receptor. TLR4 deficiency can lead to Inflammatory bowel disease. To explore the role of TLR4, we used CRISPR/Cas9 system to produce TLR4 compound heterozygous knockout embryonic stem cells in H9...

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Príomhchruthaitheoirí: Yongjuan Ruan, Xiaoxu Tian, Xiaowei Li, Youjian Zhang
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Elsevier 2023-12-01
Sraith:Stem Cell Research
Rochtain ar líne:http://www.sciencedirect.com/science/article/pii/S1873506123002118
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