CDK1-mediated phosphorylation of LDHA fuels mitosis through LDHB-dependent lactate oxidation

Abstract While cancer cells overexpress lactate dehydrogenase A (LDHA) to support glycolytic flux and lactate production, the role of LDHB—which preferentially catalyzes lactate oxidation—remains unclear. Here, we demonstrate that LDHB, but not LDHA, is essential for mitotic progression in cancers....

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Bibliographic Details

Main Authors:	Mengting Liu, Aoxing Cheng, Weiyi You, Jiaxin Wu, Chenxu Dai, Ting Wang, Ying Wu, Fumei Zhong, Jue Shi, Yingying Du, Zhonghuai Hou, Ping Gao, Ke Ruan, Yi Yang, Yuzheng Zhao, Kaiguang Zhang, Zhenye Yang, Jing Guo
Format:	Artigo
Language:	Inglês
Published:	Springer Nature 2025-09-01
Series:	EMBO Reports
Subjects:	Lactate Mitosis Lactate Dehydrogenase NADH ATP
Online Access:	https://doi.org/10.1038/s44319-025-00573-8
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