New frontiers in porcine atrioventricular node decellularization: preserving extracellular matrix architecture for biological scaffolds

IntroductionCardiac implantable electronic devices manage arrhythmias but are limited by mechanical failures, infection risks, and poor long-term biocompatibility. Developing a biological alternative that restores intrinsic pacemaking remains a key clinical challenge.MethodsWe developed cardiac scaf...

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Principais autores:	Alice Tomas, Assunta Fabozzo, Domenico Ventrella, Nunzia Gallo, Alberto Elmi, Nicola Pradegan, Lucia Santorelli, Luisa Vera Muscatello, Tiziana Palmosi, Agnese Lauroja, Deborah Sandrin, Selena Mimmi, Ricardo Malvicini, Giada De Lazzari, Enrico Iaccino, Filippo Romanato, Giuseppe Sarli, Paolo Grumati, Luca Salvatore, Alessandro Sannino, Maria Laura Bacci, Anna Maria Tolomeo, Gino Gerosa
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-03-01
Series:	Frontiers in Bioengineering and Biotechnology
Assuntos:	atrioventricular node biological pacemaker cardiac scaffold decellularized extracellular matrix (dECM) tergitol-based protocol
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fbioe.2026.1766378/full
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