Mass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress

Thiol-based post-translational modifications (PTMs) play a key role in redox-dependent regulation and signaling. Functional cysteine (Cys) sites serve as redox switches, regulated through multiple types of PTMs. Herein, we aim to characterize the complexity of thiol PTMs at the proteome level throug...

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Hauptverfasser:	Xiaolu Li, Nicholas J. Day, Song Feng, Matthew J. Gaffrey, Tai-Du Lin, Vanessa L. Paurus, Matthew E. Monroe, Ronald J. Moore, Bin Yang, Ming Xian, Wei-Jun Qian
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2021-10-01
Schriftenreihe:	Redox Biology
Schlagworte:	Protein thiols Thiol redox modifications Direct detection Post-translational modifications Redox proteomics
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2213231721002706
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