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Investigating the association of the effect of genetically proxied PCSK9i with mood disorders using cis-pQTLs: A drug-target Mendelian randomization study.

PCSK9-inhibitors (PCSK9i) are new drugs recently approved to lower LDL-cholesterol levels. However, due to the lack of long-term clinical data, the potential adverse effects of long-term use are still unknown. The PCSK9 genetic locus has been recently implicated in mood disorders and hence we wanted...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Alisha Aman, Eric A W Slob, Joey Ward, Naveed Sattar, Rona J Strawbridge
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science (PLoS) 2024-01-01
Σειρά:PLoS ONE
Διαθέσιμο Online:https://doi.org/10.1371/journal.pone.0310396
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