Higher proportions of circulating CXCR3+ CCR6− Tfh cells as a hallmark of impaired CD4+ T-cell recovery in HIV-1-infected immunological non-responders

ABSTRACT Despite long-term suppressive antiretroviral therapy (ART), immune dysregulation due to impaired reconstitution of CD4+ T cells is a major hurdle for reducing morbidity and mortality in HIV-1-infected immunological non-responders (INRs, CD4+ T cells ≤350 cells/µL). To evaluate potential imm...

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Autori principali:	Ruthu Nagaraju, Pruthvi S. Gowda, Durai M. Gunasekaran, Anita S. Desai, Udaykumar Ranga, Ramesh N. R. Masthi, Manjunatha M. Venkataswamy
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2025-05-01
Serie:	mBio
Soggetti:	HIV-1 immunological non-responders altered CD4+ T-cell subsets impaired immunological reconstitution circulatory T follicular helper cells cTfh
Accesso online:	https://journals.asm.org/doi/10.1128/mbio.00575-25
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