Cryo-EM structures of Nipah virus polymerases and high-throughput biochemical RdRp assay development enable anti-NiV drug discovery

The transcription and replication of Nipah virus (NiV) is driven by the large protein (L) and its essential co-factor phosphoprotein (P). L encodes all the viral enzymatic functions including RNA-dependent RNA polymerase (RdRp) activity while P functions as a multi-modular tetramer. To understand th...

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Principais autores:	Ahmed Rohaim, Colin Deniston, Zhenhang Chen, Cosmo Buffolo, Tiffany Tsang, Lilli Xie, Michael DiDonato, Glen Spraggon, Matt Clifton, Nadine Jarrousse, Judith Straimer, Bo Liang
Formato:	Artigo
Idioma:	Inglês
Publicado:	AIP Publishing LLC and ACA 2025-10-01
Series:	Structural Dynamics
Acceso en liña:	https://pubs.aip.org/aca/sdy/article-pdf/12/5_Supplement/A274/20775487/a274_1_4.0001063.pdf
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