p27^Kip1 and Tumors: Characterization of <i>CDKN1B</i> Variants Identified in MEN4 and Breast Cancer

p27^Kip1 is a key cell cycle gatekeeper governing the timing of Cyclin-dependent kinase (CDK) activation/inactivation and, consequently, cell proliferation. Structurally, the protein is largely unfolded, a feature that strongly increases its plasticity and interactors and enhances the numb...

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Detalhes bibliográficos

Principais autores:	Debora Bencivenga, Emanuela Stampone, Jahanzaib Azhar, Daniela Parente, Waqar Ali, Vitale Del Vecchio, Fulvio Della Ragione, Adriana Borriello
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-01-01
coleção:	Cells
Assuntos:	p27<sup>Kip1</sup> <i>CDKN1B</i> cell cycle cell motility tumor suppressor gene cancer
Acesso em linha:	https://www.mdpi.com/2073-4409/14/3/188
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