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Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect

Abstract Background Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient’s lives. These are multi-mediated pathologies that cannot be effectively protected and/or treated. Therefore,...

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Principais autores: Renata Gonçalves Dias, Sandra Coccuzzo Sampaio, Morena Brazil Sant’Anna, Fernando Queiroz Cunha, José María Gutiérrez, Bruno Lomonte, Yara Cury, Gisele Picolo
Formato: Artigo
Idioma:Inglês
Publicado em: SciELO 2017-04-01
coleção:Journal of Venomous Animals and Toxins including Tropical Diseases
Assuntos:
Lys49-PLA2
Myotoxin II
Arthritis
Bothrops asper
Phospholipase
Acesso em linha:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100307&lng=en&tlng=en
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