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A gene based approach to test genetic association based on an optimally weighted combination of multiple traits.

There is increasing evidence showing that pleiotropy is a widespread phenomenon in complex diseases for which multiple correlated traits are often measured. Joint analysis of multiple traits could increase statistical power by aggregating multiple weak effects. Existing methods for multiple trait as...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Jianjun Zhang, Qiuying Sha, Guanfu Liu, Xuexia Wang
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Public Library of Science (PLoS) 2019-01-01
Rangatū:PLoS ONE
Urunga tuihono:https://doi.org/10.1371/journal.pone.0220914
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