MEK inhibition remodels the active chromatin landscape and induces SOX10 genomic recruitment in BRAF(V600E) mutant melanoma cells

Abstract Background The MAPK/ERK signaling pathway is an essential regulator of numerous cell processes that are crucial for normal development as well as cancer progression. While much is known regarding MAPK/ERK signal conveyance from the cell membrane to the nucleus, the transcriptional and epige...

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Detalhes bibliográficos

Principais autores:	Temesgen D. Fufa, Laura L. Baxter, Julia C. Wedel, Derek E. Gildea, NISC Comparative Sequencing Program, Stacie K. Loftus, William J. Pavan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-08-01
coleção:	Epigenetics & Chromatin
Assuntos:	Pigmentation Melanocyte MAPK pathway MEK inhibitor Enhancers SOX10
Acesso em linha:	http://link.springer.com/article/10.1186/s13072-019-0297-2
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