AXL is a novel ERK5/KLF4 target in MEK inhibitor-treated melanoma

RAS/RAF/MEK/ERK1/2 mitogen-activated protein kinase (MAPK) pathway-based treatments, typically combination therapies with inhibitors for oncogenic BRAF V600 (BRAFi) and MEK1/2 (MEKi), are important treatment alternatives to immunotherapy in advanced BRAF-mutated melanoma. However, their benefit is l...

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Principais autores:	Rupesh Paudel, Simon Goller, Stefanie Schwarz, Katharina Meder, Matthias Goebeler, Marc Schmidt
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2026-06-01
叢編:	Neoplasia: An International Journal for Oncology Research
主題:	NRAS-mutant melanoma Therapy resistance MEK5/ERK5 pathway AXL KLF2 KLF4
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S1476558626000308
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