Biophysical characterization of Eag chaperones suggests the mechanism of effector transmembrane domain release

Abstract The type VI secretion system (T6SS) is a dynamic protein nanomachine found in Gram-negative bacteria that secretes toxic effectors into prey-cells. For secretion, effectors require chaperones or adaptors for proper loading onto the T6SS. Effector associated genes (Eags) are a family of T6SS...

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Autores principales:	Matthew Van Schepdael, Iman Asakereh, Jake Colautti, Andrew J. Gierys, Kartik Sachar, Shehryar Ahmad, Mazdak Khajehpour, John C. Whitney, Gerd Prehna
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2026-01-01
Colección:	Nature Communications
Acceso en línea:	https://doi.org/10.1038/s41467-025-68138-w
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