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Revisiting the evolution of bow-tie architecture in signaling networks

Abstract Bow-tie architecture is a layered network structure that has a narrow middle layer with multiple inputs and outputs. Such structures are widely seen in the molecular networks in cells, suggesting that a universal evolutionary mechanism underlies the emergence of bow-tie architecture. The pr...

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Autores principales: Thoma Itoh, Yohei Kondo, Kazuhiro Aoki, Nen Saito
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Portfolio 2024-06-01
Colección:npj Systems Biology and Applications
Acceso en línea:https://doi.org/10.1038/s41540-024-00396-8
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