N-linked glycans on the stalk of influenza virus neuraminidase promote functional tetramer formation by compensating for local hydrophobicity

ABSTRACT Enveloped virus surface antigens, such as influenza neuraminidase (NA), typically depend on N-linked glycans for assembly, trafficking in the host cell, and immune evasion. Here, we examined the function of the N-linked glycans on the NA stalk from H1N1 2009 pandemic (pdm09) viruses using r...

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Autors principals:	Soma Saeidi, Hongquan Wan, Hyeog Kang, Jin Gao, Wells W. Wu, Tahir Malik, Robert Daniels
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology 2025-09-01
Col·lecció:	Journal of Virology
Matèries:	influenza surface antigens glycoprotein maturation antigen engineering N-linked glycosylation immunogenicity recombinant vaccine antigens
Accés en línia:	https://journals.asm.org/doi/10.1128/jvi.00879-25
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