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Fully Characterized Mature Human iPS- and NMP-Derived Motor Neurons Thrive Without Neuroprotection in the Spinal Contusion Cavity

Neural cell interventions in spinal cord injury (SCI) have focused predominantly on transplanted multipotent neural stem/progenitor cells (NSPCs) for animal research and clinical use due to limited information on survival of spinal neurons. However, transplanted NSPC fate is unpredictable and largel...

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Main Authors: Zachary T. Olmsted, Cinzia Stigliano, Brandon Marzullo, Jose Cibelli, Philip J. Horner, Janet L. Paluh
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
spinal cord injury
spinal motor neuron
neuromesodermal progenitor
oligodendrocyte progenitor cell
neuron transplantation
neuron survival
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2021.725195/full
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