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Evaluation of Four Adjuvant Combinations, IVAX-1, IVAX-2, CpG-1826+Montanide ISA 720 VG and CpG-1018+Montanide ISA 720 VG, for Safety and for Their Ability to Elicit Protective Immune Responses in Mice against a Respiratory Challenge with <i>Chlamydia muridarum</i>

There is an urgent need to produce a vaccine for <i>Chlamydia trachomatis</i> infections. Here, using the <i>Chlamydia muridarum</i> major outer membrane protein (MOMP) as an antigen, four adjuvant combinations IVAX-1 (MPLA+CpG-1018+AddaVax), IVAX-2 (MPLA+CpG-1018+AS03), CpG-1826+Montanide ISA 720 V...

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Gardado en:
Principais autores: Sukumar Pal, Anatoli Slepenkin, Jiin Felgner, D. Huw Davies, Philip Felgner, Luis M. de la Maza
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2023-06-01
Series:Pathogens
Assuntos:
<i>Chlamydia trachomatis</i>
<i>Chlamydia muridarum</i>
vaccine
adjuvant combinations
major outer membrane protein
mice
Acceso en liña:https://www.mdpi.com/2076-0817/12/7/863
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