Amino acid substitutions in NSP6 and NSP13 of SARS-CoV-2 contribute to superior virus growth at low temperatures

ABSTRACT In general, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates well at 37°C, which is the temperature of the human lower respiratory tract, but it poorly at 30°C‒32°C, which is the temperature of the human upper respiratory tract. The replication efficiency of SARS-CoV-...

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Autori principali:	Yuri Furusawa, Maki Kiso, Ryuta Uraki, Yuko Sakai-Tagawa, Hiroyuki Nagai, Michiko Koga, Yukie Kashima, Masayuki Hojo, Noriko Iwamoto, Kiyoko Iwatsuki-Horimoto, Norio Ohmagari, Yutaka Suzuki, Hiroshi Yotsuyanagi, Peter J. Halfmann, Wataru Kamitani, Seiya Yamayoshi, Yoshihiro Kawaoka
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2025-03-01
Serie:	Journal of Virology
Soggetti:	SARS-CoV-2 COVID-19 coronavirus
Accesso online:	https://journals.asm.org/doi/10.1128/jvi.02217-24
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