Targeting of Janus Kinases Limits Pro-Inflammatory but Also Immunosuppressive Circuits in the Crosstalk between Synovial Fibroblasts and Lymphocytes

Crosstalk between synovial fibroblasts (SF) and immune cells plays a central role in the development of rheumatoid arthritis (RA). Janus kinase inhibitors (JAKi) have proven efficacy in the treatment of RA, although clinical responses are heterogeneous. Currently, little is known regarding how JAKi...

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Автори:	Nina Yao, Theresa Tretter, Peter Kvacskay, Wolfgang Merkt, Norbert Blank, Hanns-Martin Lorenz, Lars-Oliver Tykocinski
Формат:	Artigo
Мова:	Inglês
Опубліковано:	MDPI AG 2021-10-01
Серія:	Biomedicines
Предмети:	janus kinases JAK inhibitors tofacitinib baricitinib upadacitinib rheumatoid arthritis
Онлайн доступ:	https://www.mdpi.com/2227-9059/9/10/1413
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