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Impact of proton pump inhibitor use on clinical outcomes in East Asian patients receiving clopidogrel following drug-eluting stent implantation

Abstract Background Concomitant use of clopidogrel and proton pump inhibitor (PPI) is common, but PPI may reduce the antiplatelet effects of clopidogrel in patients undergoing percutaneous coronary intervention (PCI). We evaluated the impact of PPI use on clinical outcomes in post-PCI patients, by i...

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Principais autores: Ju Hyeon Kim, Soon Jun Hong, Jung-Joon Cha, Subin Lim, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Tae Hoon Ahn, Young-Hoon Jeong, Byeong-Keuk Kim, Kiyuk Chang, Yongwhi Park, Young Bin Song, Sung Gyun Ahn, Jung-Won Suh, Sang Yeub Lee, Jung Rae Cho, Ae-Young Her, Hyo-Soo Kim, Moo Hyun Kim, Eun-Seok Shin, Do-Sun Lim
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-08-01
coleção:BMC Medicine
Assuntos:
Clopidogrel
Proton pump inhibitor
Platelet reactivity
Poor metabolizer
Myocardial infarction
Bleeding
Acesso em linha:https://doi.org/10.1186/s12916-024-03549-y
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