Crystal structures of the carboxyl cGMP binding domain of the Plasmodium falciparum cGMP-dependent protein kinase reveal a novel capping triad crucial for merozoite egress.

The Plasmodium falciparum cGMP-dependent protein kinase (PfPKG) is a key regulator across the malaria parasite life cycle. Little is known about PfPKG's activation mechanism. Here we report that the carboxyl cyclic nucleotide binding domain functions as a "gatekeeper" for activation by providing the...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Jeong Joo Kim, Christian Flueck, Eugen Franz, Eduardo Sanabria-Figueroa, Eloise Thompson, Robin Lorenz, Daniela Bertinetti, David A Baker, Friedrich W Herberg, Choel Kim
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Public Library of Science (PLoS) 2015-02-01
Цуврал:	PLoS Pathogens
Онлайн хандалт:	https://doi.org/10.1371/journal.ppat.1004639
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!