Genetic variations in HMGCR and PCSK9 and kidney function: a Mendelian randomization study

Background The genetically predicted lipid-lowering effect of HMGCR or PCSK9 variant can be used to assess drug proxy effects on kidney function. Methods Mendelian randomization (MR) analysis-identified HMGCR and PCSK9 genetic variants were used to predict the low-density lipoprotein (LDL) cholester...

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Hlavní autoři:	Sehoon Park, Seong Geun Kim, Soojin Lee, Yaerim Kim, Semin Cho, Kwangsoo Kim, Yong Chul Kim, Seung Seok Han, Hajeong Lee, Jung Pyo Lee, Kwon Wook Joo, Chun Soo Lim, Yon Su Kim, Dong Ki Kim
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	The Korean Society of Nephrology 2023-07-01
Edice:	Kidney Research and Clinical Practice
Témata:	chronic kidney disease dyslipidaemia mendelian randomization statin
On-line přístup:	http://www.krcp-ksn.org/upload/pdf/j-krcp-22-237.pdf
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