Poly-3-hydroxybutyrate-co-3-hydroxyvalerate(PHBV)-Polyethylene glycol 20k(PEG20k) as a promising delivery system for PT2399 in the treatment of disc degeneration

Abstract Disc degeneration often leads to a highly prevalent symptom known as low back pain. Healthy nucleus pulposus tissue exhibited a hypoxic environment devoid of blood vessels, while degenerated nucleus pulposus experienced hypoxic deterioration and the formation of new blood vessels. In this s...

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Principais autores:	Zhencong Li, Weilin Zhang, Shengbang Huang, Zhiwen Dai, Jinguo Liang, Qiulan Qiu, Siyuan Chen, Weixiong Guo, Zhongwei Wang, Jinsong Wei
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2024-01-01
Series:	Journal of Biological Engineering
Assuntos:	PHBV Nucleus pulposus HIF-2α PT2399 Anoxic environment
Acceso en liña:	https://doi.org/10.1186/s13036-024-00407-6
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