Intratumoral Gene Electrotransfer of Plasmid DNA Encoding shRNA against Melanoma Cell Adhesion Molecule Radiosensitizes Tumors by Antivascular Effects and Activation of an Immune Response

In this study, radiotherapy was combined with the gene electrotransfer (GET) of plasmid encoding shRNA against melanoma cell adhesion molecule (pMCAM) with dual action, which was a vascular-targeted effect mediated by the silencing of MCAM and an immunological effect mediated by the presence of plas...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Simona Kranjc Brezar, Valter Mrak, Masa Bosnjak, Monika Savarin, Gregor Sersa, Maja Cemazar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-03-01
coleção:	Vaccines
Assuntos:	melanoma cell adhesion molecule sirna gene electrotransfer irradiation vascular targeted effect immune response mouse melanoma model mouse carcinoma model
Acesso em linha:	https://www.mdpi.com/2076-393X/8/1/135
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!