Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.

Herpes simplex encephalitis (HSE) is a lethal neurological disease resulting from infection with Herpes Simplex Virus 1 (HSV-1). Loss-of-function mutations in the UNC93B1, TLR3, TRIF, TRAF3, and TBK1 genes have been associated with a human genetic predisposition to HSE, demonstrating the UNC93B-TLR3...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Grégory Caignard, Gabriel A Leiva-Torres, Michael Leney-Greene, Benoit Charbonneau, Anne Dumaine, Nassima Fodil-Cornu, Michal Pyzik, Pablo Cingolani, Jeremy Schwartzentruber, Jeremy Dupaul-Chicoine, Huaijian Guo, Maya Saleh, André Veillette, Marc Lathrop, Mathieu Blanchette, Jacek Majewski, Angela Pearson, Silvia M Vidal
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Public Library of Science (PLoS) 2013-09-01
Sarja:	PLoS Pathogens
Linkit:	http://europepmc.org/articles/PMC3771889?pdf=render
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