AMPAR dysregulation in microglia drives vascular pathology in diabetic retinopathy via the P2X7R/NLRP3/IL-1β pathway

Abstract Background Diabetic retinopathy (DR) is a leading cause of visual impairment in working-age adults globally, characterized by chronic retinal inflammation and inner blood-retinal barrier (iBRB) disruption. Glutamate excitotoxicity and microglial activation are key pathogenic contributors, b...

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Egile Nagusiak:	Lili Zhang, Kaixiang Li, Fengjuan Gao, Jiaojiao Wei, Xin Chen, Gezhi Xu, Yuan Zong, Ting Zhang
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2026-04-01
Saila:	Journal of Translational Medicine
Gaiak:	Diabetic retinopathy AMPAR Calcium-permeable AMPAR Microglia P2X7R NLRP3 inflammasome
Sarrera elektronikoa:	https://doi.org/10.1186/s12967-026-08195-x
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