Protein kinase C epsilon deletion in AgRP neurons modulates hypothalamic glucose sensing and improves glucose tolerance in mice

Objectives: Global but not liver-specific deletion of protein kinase C epsilon (PKCε) improves glucose tolerance in fat-fed mice, suggesting that extra-hepatic tissues are involved. AgRP neurons within the arcuate nucleus (ARC) of the hypothalamus can affect glucose homeostasis acutely, in addition...

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Egile Nagusiak:	Amanda E. Brandon, Chenxu Yan, Xuan Zhang, Chi Kin Ip, Zhongmin Gao, Nicola J. Lee, Oana C. Marian, Alex Perez, Anthony S. Don, Herbert Herzog, Lewin Small, Yan-Chuan Shi, Carsten Schmitz-Peiffer
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2026-02-01
Saila:	Molecular Metabolism
Gaiak:	AgRP neuron Glucose intolerance High-fat diet Hypothalamus Protein kinase C epsilon
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2212877826000049
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