Stretch‐Induced Increase in Ca2+‐Spark Rate in Rabbit Atrial Cardiomyocytes Requires TRPA1 and Intact Microtubule Network

Background Mechanical stretch of the myocardium is proarrhythmic and alters cellular Ca2+ handling, potentially involving cation nonselective mechano‐sensitive ion channels. This study aimed to assess the presence and mechanisms of stretch‐induced increase in Ca2+‐spark rate (SiS) in isolated atrial...

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Detalhes bibliográficos

Principais autores:	Jiaying Fu, Breanne A. Cameron, Patrick Schönleitner, Teresa Schiatti, Marion Kuiper, Anna‐Sophia Kittel, Ana Simon‐Chica, Josef Madl, Clemens Kreutz, David Filgueiras‐Rama, Ulrich Schotten, Winfried Römer, Ursula Ravens, Peter Kohl, Eva A. Rog‐Zielinska, Gudrun Antoons, Rémi Peyronnet
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2025-09-01
coleção:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Assuntos:	atrial electrophysiology mechano‐transduction stretch‐activated ion channels
Acesso em linha:	https://www.ahajournals.org/doi/10.1161/JAHA.124.040495
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