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Ceftazidime/avibactam resistance is associated with PER-3-producing ST309 lineage in Chilean clinical isolates of non-carbapenemase producing Pseudomonas aeruginosa

IntroductionCeftazidime/avibactam (CZA) is indicated against multidrug-resistant Pseudomonas aeruginosa, particularly those that are carbapenem resistant. CZA resistance in P. aeruginosa producing PER, a class A extended-spectrum β-lactamase, has been well documented in vitro. However, data regardin...

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Principais autores: Katherine D. Soto, Manuel Alcalde-Rico, Juan A. Ugalde, Jorge Olivares-Pacheco, Valeria Quiroz, Bárbara Brito, Lina M. Rivas, José M. Munita, Patricia C. García, Aniela Wozniak
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-06-01
Serier:Frontiers in Cellular and Infection Microbiology
Fag:
Pseudomonas aeruginosa
blaPER-3 gene
PER-3 extended-spectrum β-lactamase
ceftazidime/avibactam resistance
mutations conferring CZA resistance
Online adgang:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1410834/full
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