From “lysosomal addiction” to targeted therapies: exploiting novel windows in colorectal cancer

Abstract Patients with advanced-stage or treatment-resistant colorectal cancer (CRC) face limited therapeutic options with conventional therapies, necessitating novel treatment strategies. CRC cells exhibit "lysosomal addiction" through enhanced autophagy-lysosomal flux and upregulated lysosome-asso...

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Bibliografski detalji

Glavni autori:	Xiaoyu Wang, Fan An, Benjun Wang, Tiantian Zhang, Yueting Fang, Liwei Yan, Chuan Jiang, Wenwen Cui, Weiwei Han
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-10-01
Serija:	European Journal of Medical Research
Teme:	Colorectal cancer Lysosome Ferroptosis Autophagy Immunotherapy Drug resistance
Online pristup:	https://doi.org/10.1186/s40001-025-03145-7
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