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Geranylgeranyl isoprenoids and hepatic Rap1a regulate basal and statin-induced expression of PCSK9

LDL-C lowering is the main goal of atherosclerotic cardiovascular disease prevention, and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is now a validated therapeutic strategy that lowers serum LDL-C and reduces coronary events. Ironically, the most widely used medicine to lower c...

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Principais autores: Yating Wang, Brea Tinsley, Stefano Spolitu, John A. Zadroga, Heena Agarwal, Amesh K. Sarecha, Lale Ozcan
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-03-01
Serier:Journal of Lipid Research
Fag:
PCSK9
LDL
Rap1a
statins
geranylgeranylation
Online adgang:http://www.sciencedirect.com/science/article/pii/S0022227524000208
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