BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells

To decrease bowel cancer incidence and improve survival, we need to understand the mechanisms that drive tumorigenesis. Recently, B-cell lymphoma 3 (BCL-3; a key regulator of NF-κB signalling) has been recognised as an important oncogenic player in solid tumours. Although reported to be overexpresse...

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Autori principali:	Danny N. Legge, Alex P. Shephard, Tracey J. Collard, Alexander Greenhough, Adam C. Chambers, Richard W. Clarkson, Christos Paraskeva, Ann C. Williams
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	The Company of Biologists 2019-03-01
Serie:	Disease Models & Mechanisms
Soggetti:	NF-kappaB NF-κB LGR5 ASCL2 Wnt Spheroid BCL3
Accesso online:	http://dmm.biologists.org/content/12/3/dmm037697
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